Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis
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Determination of Triptonide and Triptolide in Multi-glycosides Tripterygium Wilfordii Tablets by Capillary Electrophoresis
A capillary electrophoresis method has been established for the determination of triptonide and triptolide in Multi-glycosides Tripterygium wilfordii tablets. Capillary separation was carried out by using 0.01mol L borax + 0.02 mol L boric acid + 0.02 mol L SDS (pH = 8.0) as the buffer, a fused – silica capillary tube column (60.2 cm × 75μm id. 52.6 cm of effective length) as the separation cha...
متن کاملIsolation and Purification of Triptolide from the Leaves of Tripterygium wilfordii Hook F
Triptolide is an important active component of Tripterygium wilfordii Hook F (TWHF) and possesses anti-inflammatory, immunosuppressive, male anti-fertility, and anticancer properties. A new method combining different techniques, including solid-liquid extraction, liquid-liquid partition, column chromatography and high-speed counter-current chromatography (HSCCC) but avoiding the use of chlorofo...
متن کاملA Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxic...
متن کاملTerpene alkaloids from Tripterygium wilfordii.
Two new sesquiterpene alkaloids, 1beta-hydroxy-2beta,5alpha,11-triacetoxy-7beta-nicotinoyl-8beta-benzoyl-dihydroagarofuran, and 1beta,5alpha,11-triacetoxy-7beta-nicotinoyl-8beta-benzoyl-dihydroagarofuran were isolated from the xylem of Tripterygium wilfordii, together with six known compounds. Their structures were elucidated on the basis of spectroscopic studies.
متن کاملDifferent modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine
Background Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney. Methods The absorption of triptolide, triptonide, wilforlide and tripter...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14776-1